Fluoxetine Dose and Administration Method Differentially Affect Hippocampal Plasticity in Adult Female Rats
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چکیده
منابع مشابه
Fluoxetine Dose and Administration Method Differentially Affect Hippocampal Plasticity in Adult Female Rats
Selective serotonin reuptake inhibitor medications are one of the most common treatments for mood disorders. In humans, these medications are taken orally, usually once per day. Unfortunately, administration of antidepressant medications in rodent models is often through injection, oral gavage, or minipump implant, all relatively stressful procedures. The aim of the present study was to investi...
متن کاملNeurobiology of Disease Chronic Fluoxetine Stimulates Maturation and Synaptic Plasticity of Adult-Born Hippocampal Granule Cells
Jing-Wen Wang,1,4 Denis J. David,2 James E. Monckton,4 Fortunato Battaglia,3 and René Hen4 1Department of Biological Sciences, Columbia University, New York, New York 10027, 2EA 3544 Faculte de Pharmacy, Universite Paris-Sud, ChatenayMalabry 92296, France, 3Department of Physiology and Pharmacology, City College of New York, New York, New York 10031, and 4Departments of Neuroscience and Psychia...
متن کاملChronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells.
Chronic treatments with selective serotonin reuptake inhibitors (SSRIs) have been shown to increase hippocampal neurogenesis. However, it is not known whether SSRIs impact the maturation and functional integration of newborn neurons. Here we examined the effects of subchronic and chronic fluoxetine on the structural and physiological properties of young granule cells. Our results show that doub...
متن کاملHippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice
Current antidepressant treatments to anxiety and depression remain inadequate, burdened by a significant percentage of misuse and drug side-effects, due to unclear mechanisms of actions of antidepressants. To better understand the regulatory roles of antidepressant fluoxetine-related drug reactions, we here investigate changes of expression levels of hippocampal microRNAs (miRNAs) after adminis...
متن کاملEstradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats
Estradiol increases cell proliferation in the dentate gyrus of the female rodent but it is not known whether the G protein-coupled estrogen receptor (GPER), a membrane receptor, is involved in this process, nor whether there are regional differences in estradiol's effects on cell proliferation. Thus, we investigated whether estradiol exerts its effects on cell proliferation in the dorsal and ve...
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ژورنال
عنوان ژورنال: Neural Plasticity
سال: 2014
ISSN: 2090-5904,1687-5443
DOI: 10.1155/2014/123026